From 1 to 100, how many numbers have exactly six divisors

It should be 16

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2. If the circle x ^ 2 + y ^ 2 + DX + ey + F = 0 (d ^ 2 + e ^ 2-4f) is symmetric with respect to the straight line x + y = 0, then the following equation holds true A、D+E+F=0 B、D+F=0 C、D+E=0 D、E+F=0
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20. If the circle x ^ 2 + y ^ 2 + DX + ey + F = 0 (d ^ 2 + e ^ 2-4f > 0) is symmetric with respect to the line y = x + 1, then A D+E=2 B D+E=1 C D-E=2 D D-E=1